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Published on: May 15, 2019
Treatment of pediatric refractory Crohn's disease with thalidomide
Cui-Fang Zheng1, Jia-Hua Xu, Ying Huang
1Department of Gastroenterology, Children's Hospital of Fudan University, Shanghai 201102, China.
Aim:
To assess the efficacy and tolerability of thalidomide in pediatric Crohn's disease (CD).
Methods:
Six patients with refractory CD received thalidomide at an initial dose of 2 mg/kg per day for one month, then increased to 3 mg/kg per day or decreased to 1 mg/kg per day, and again further reduced to 0.5 mg/kg per day, according to the individual patient's response to the drug.
Results:
Remission was achieved within three months. Dramatic clinical improvement was demonstrated after thalidomide treatment. Endoscopic and pathological improvements were also observed after thalidomide treatment, which was well tolerated by all patients.
Conclusion:
Thalidomide is a useful drug for pediatric refractory CD.
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