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Updated: Jun 3, 2026

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Published on: September 8, 2021
Hypothalamic digoxin and schizophrenia - a model for conscious and subliminal perception and its dysfunction in
R A Kurup1, J Augustine, P A Kurup
1A. RAVIKUMAR KURUP, MD., DM., MNAMS, Assistant Professor of Neurology, Medical college Hospital, Trivandrum.
Abstract:
In view of reports of an upregulated cation pump in genetically related Bipolar Affective Disorders the role of hypothalamic digoxin, an endogenous regulator of the cation pump was studied with special reference to its role as a modulator of glycoprotein synthesis. The study demonstrated elevated serum digoxin levels, elevated HMG CoA reductase activity suggesting increased digoxin synthesis, reduced sodium-potassium ATPase activity and altered sugar residues of serum glycoprotein in schizophrenia. A hypothalamic digoxin mediated model for conscious and subliminal perception is proposed and the significance of its dysfunction due to abnormal glycoprotein induced synaptic connectivity defects in schizophrenia is discussed.
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