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Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials
Published on: June 25, 2018
Foldamers containing γ-amino acid residues or their analogues: structural features and applications
Francelin Bouillère1, Sophie Thétiot-Laurent, Cyrille Kouklovsky
1Université Paris-Sud, CNRS, Laboratoire de Chimie des Procédés et Substances Naturelles, ICMMO, UMR 8182, Bât 410, 91405 Orsay, France.
Abstract:
Over the past 20 years, the field of foldamers has rapidly increased. Many β-peptides have already been described and shown interesting properties. γ-Peptides have more recently emerged but seem to be very interesting as well. In this review, we will cover every peptidomimetic oligomer that contains a γ-amino acid or an analogue and presents a structural feature. It includes γ-peptides but also hybrid α-γ peptides, β-γ peptides and analogues such as oligoureas or aminoxy acids. We will present the biological properties of these oligomers.
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