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Related Experiment Video

Updated: Jun 3, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Transferrin changes in haemodialysed patients.

Dorota Formanowicz¹, Piotr Formanowicz

¹Department of Clinical Biochemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland. doforman@ump.edu.pl

International Urology and Nephrology

|April 2, 2011

Summary

Transferrin (Tf) levels and variants change in patients undergoing maintenance hemodialysis (mHD). Decreased renal function, longer mHD duration, and inflammation impact Tf microheterogeneity, potentially explaining persistent anemia.

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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

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Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

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Published on: October 2, 2020

Area of Science:

Biochemistry
Nephrology
Clinical Chemistry

Background:

Transferrin (Tf) is a key iron transport glycoprotein.
Tf exhibits microheterogeneity with four physiological variants (Tf1-Tf4).
Tf alterations are observed during acute phase responses and in end-stage renal disease.

Purpose of the Study:

To investigate changes in Tf concentration and microheterogeneity in maintenance hemodialysis (mHD) patients.
To assess Tf variations during the course of mHD treatment.
To identify factors influencing Tf microheterogeneity in mHD patients.

Main Methods:

Studied 80 mHD patients and 21 healthy volunteers.
Measured Tf concentration using rocket immunoelectrophoresis.
Assessed Tf microheterogeneity via ConA crossed immunoaffinity electrophoresis.

Main Results:

Observed changes in the percentage content of all Tf variants.
Found a significant decrease in serum concentrations of Tf2, Tf3, and Tf4.
Identified decreased renal function, mHD duration, and inflammation as contributing factors.

Conclusions:

Tf microheterogeneity is altered in mHD patients.
Renal function, mHD duration, and inflammation influence these Tf changes.
These Tf alterations may contribute to the persistence of anemia in hemodialysis patients.