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Short-term antimicrobial properties of mineral trioxide aggregate with incorporated silver-zeolite

Mesut E Odabaş1, Cağdaş Cinar, Gülçin Akça

  • 1Departments of Pediatric Dentistry Microbiology, Faculty of Dentistry, University of Gazi Department of Chemical Engineering, Faculty of Engineering, University of Middle East Technical, Ankara, Turkey. mesut@gazi.edu.tr

Dental Traumatology : Official Publication of International Association for Dental Traumatology
|April 5, 2011
PubMed

Insights

Adding silver-zeolite (SZ) to mineral trioxide aggregate (MTA) enhanced its antimicrobial activity against several bacteria and fungi. While MTA alone showed some antimicrobial effects, SZ incorporation boosted efficacy, with higher silver ion release observed.

Area of Science:

  • Dental Materials Science
  • Antimicrobial Research
  • Biomaterials Engineering

Background:

  • Mineral trioxide aggregate (MTA) is a widely used dental material.
  • Concerns exist regarding MTA's inherent antimicrobial efficacy against a broad spectrum of pathogens.
  • Enhancing MTA's antimicrobial properties is crucial for improving clinical outcomes.

Purpose of the Study:

  • To investigate the effect of incorporating silver-zeolite (SZ) into MTA.
  • To evaluate the enhanced antimicrobial activity of SZ-modified MTA against specific oral microorganisms.
  • To assess silver ion release and pH changes associated with SZ-MTA.

Main Methods:

  • In vitro study using MTA mixed with 0.2% and 2% SZ.
  • Antimicrobial activity assessed via zones of inhibition against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Porphyromonas gingivalis, Actinomyces israelii, and Prevotella intermedia.
  • Silver ion release measured by atomic absorption spectrophotometry.
  • pH levels monitored using a pH meter.

Main Results:

  • MTA with 0.2% and 2% SZ demonstrated inhibitory effects against some tested microorganisms.
  • No significant antimicrobial activity was observed against Prevotella intermedia and Actinomyces israelii with SZ-MTA.
  • MTA without SZ inhibited Candida albicans, Escherichia coli, and Prevotella intermedia.
  • Highest silver ion release occurred with 2% SZ-MTA at 24 hours.

Conclusions:

  • Silver-zeolite incorporation potentially enhances the antimicrobial activity of mineral trioxide aggregate.
  • Further research is warranted to optimize SZ concentration for broad-spectrum antimicrobial efficacy.
  • SZ-MTA shows promise as an improved dental material with enhanced antibacterial properties.

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