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Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...

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Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
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Published on: January 7, 2019

Production methods for nanodrug particles using the bottom-up approach.

Hak-Kim Chan1, Philip Chi Lip Kwok

  • 1Advanced Drug Delivery Group, The University of Sydney, Australia. kim.chan@sydney.edu.au

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|April 5, 2011
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Summary

This review explores bottom-up methods like precipitation and droplet evaporation for creating pure therapeutic nanoparticles. Controlling particle formation is key to producing stable nanoparticles for pharmaceutical use.

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10:12

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Published on: January 7, 2019

Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control
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Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

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Area of Science:

  • Pharmaceutical Nanotechnology
  • Materials Science
  • Chemical Engineering

Background:

  • Nanoparticle production is crucial for drug delivery.
  • Bottom-up approaches offer precise control over nanoparticle characteristics.
  • Achieving high purity of therapeutics within nanoparticles is essential for efficacy and safety.

Purpose of the Study:

  • To review bottom-up manufacturing techniques for pure therapeutic nanoparticles.
  • To highlight precipitation and droplet evaporation methods.
  • To identify critical parameters for stable nanoparticle formation.

Main Methods:

  • Precipitation techniques: high-gravity, confined impinging liquid jet mixing, multi-inlet vortex mixing, supercritical fluids, ultrasonic waves.
  • Droplet evaporation methods: nanospray drying, aerosol flow reactor, ambient low-boiling point solvent spraying, electrospraying.
  • Focus on controlling particle growth kinetics.

Main Results:

  • Various precipitation and droplet evaporation methods can yield pure therapeutic nanoparticles.
  • Control over evaporation or mixing rates is critical for nanoparticle stability.
  • These methods are suitable for pharmaceutical applications.

Conclusions:

  • Bottom-up manufacturing offers viable routes for producing pure therapeutic nanoparticles.
  • Precise control over process parameters is essential for successful nanoparticle synthesis.
  • These techniques hold significant promise for pharmaceutical development.