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Related Experiment Video

Updated: Jun 3, 2026

Studying Orthodontic Tooth Movement in Mice

Studying Orthodontic Tooth Movement in Mice

Published on: August 2, 2024

Tooth movement into distraction regenerate: when should we start?

Fouad Aly El Sharaby¹, Nader Nabil El Bokle, Dalia Mohamed El Boghdadi

¹Orthodontic Department, Faculty of Oral and Dental Medicine, Cairo University, Cairo, Egypt.

American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics

|April 5, 2011

Summary

Initiating orthodontic tooth movement too early after mandibular distraction osteogenesis can lead to adverse tissue reactions like root resorption. Radiographic evaluation of bone regenerate is recommended before starting tooth movement.

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Last Updated: Jun 3, 2026

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Published on: October 27, 2023

Area of Science:

Orthodontics
Regenerative Medicine
Oral and Maxillofacial Surgery

Background:

Mandibular distraction osteogenesis (MDO) is a surgical procedure to increase mandibular length.
Orthodontic tooth movement into regenerated bone following MDO requires careful timing.
Understanding the optimal window for initiating orthodontic treatment post-MDO is crucial for successful outcomes.

Purpose of the Study:

To clinically, radiographically, and histologically evaluate orthodontic tooth movement into bone regenerate after MDO.
To determine the optimal timing for initiating orthodontic tooth movement following MDO.

Main Methods:

Nine mongrel dogs underwent MDO to create an average 9 mm edentulous gap.
Dogs were divided into three groups, initiating tooth movement at 1, 3, or 6 weeks post-consolidation.
Evaluated were the rate and type of tooth movement and adverse tissue reactions (root resorption, crestal bone loss).

Main Results:

Early orthodontic tooth movement into regenerate bone resulted in analogous adverse tissue reactions.
Radiographic and histologic analyses confirmed increased root resorption and crestal bone loss with early movement.
The rate and type of tooth movement varied significantly across the three consolidation timing groups.

Conclusions:

Early initiation of orthodontic tooth movement into distraction regenerate is not recommended due to potential adverse tissue reactions.
Radiographic examination of the distraction regenerate is advised as a guide to determine the appropriate timing for initiating tooth movement.
Careful timing and radiographic assessment are essential for safe and effective orthodontic treatment following MDO.