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Gated myocardial perfusion scintigraphy in children with sickle cell anemia: correlation with echocardiography

O Hallioglu1, E Ceylan Gunay, S Unal

  • 1Mersin University, Department of Pediatric Cardiology, Turkey.

Revista Espanola De Medicina Nuclear
|April 5, 2011
PubMed

Insights

Gated myocardial perfusion scintigraphy (G-MPS) shows infrequent impairment in children with sickle cell anemia (SCA). Left ventricle (LV) dilatation and LV-MPI are key indicators, not ejection fraction (EF) or perfusion, in early stages.

Area of Science:

  • Cardiology
  • Pediatrics
  • Hematology

Background:

  • Sickle cell anemia (SCA) can affect cardiac function.
  • Early detection of cardiac involvement in pediatric SCA is crucial.

Purpose of the Study:

  • To evaluate myocardial perfusion and left ventricle (LV) function in children with SCA using gated myocardial perfusion scintigraphy (G-MPS).
  • To compare G-MPS findings with echocardiographic parameters.

Main Methods:

  • Prospective study of 43 children with SCA.
  • Evaluation using G-MPS and echocardiography.
  • Analysis of myocardial perfusion, LV function, volumes (EDV, ESV), ejection fraction (EF), and lung-to-heart (L/H) ratio.

Main Results:

  • No stress perfusion impairment observed via G-MPS.
  • LV dilatation detected in 15 patients by both G-MPS and echocardiography.
  • Normal EF values; LV dilatation correlated with echocardiographic diameters and frequent blood transfusions/acute chest syndrome.

Conclusions:

  • Myocardial perfusion impairment is uncommon in pediatric SCA.
  • LV dilatation and LV-MPI are significant early indicators, more so than EF or perfusion.
  • Consider G-MPS for symptomatic pediatric SCA patients.
Abstract

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