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Fibrin glue inhibits intra-abdominal adhesion formation
C de Virgilio1, T Dubrow, B B Sheppard
1Department of Surgery, Harbor-UCLA Medical Center, Torrance, Calif. 90509.
Archives of Surgery (Chicago, Ill. : 1960)
|October 1, 1990
Summary
Fibrin glue significantly reduces intra-abdominal adhesions in rats. Higher fibrinogen concentrations in the fibrin glue enhance its inhibitory effect on adhesion formation, promoting faster healing.
Area of Science:
- Biomedical Engineering
- Surgical Innovation
- Wound Healing Research
Background:
- Intra-abdominal adhesions are a common complication following abdominal surgery.
- Adhesions can lead to significant morbidity, including bowel obstruction and infertility.
- Current methods to prevent adhesions have limitations.
Purpose of the Study:
- To evaluate the efficacy of fibrin glue in preventing intra-abdominal adhesion formation in a rat model.
- To determine if the concentration of fibrinogen in fibrin glue affects its anti-adhesion properties.
- To assess the impact of fibrin glue on peritoneal healing.
Main Methods:
- Forty-five rats were randomized into three groups, each undergoing two adhesion models.
- Group 1 (control) received no treatment.
- Groups 2 and 3 had adhesion models treated with fibrinogen at different concentrations (1.77 g/L and 23.6 g/L, respectively).
Main Results:
- Group 1 showed high-grade adhesions in 13/15 rats.
- Group 2 exhibited reduced adhesions compared to the control (9/15 and 12/15 rats).
- Group 3 demonstrated a significant reduction in high-grade adhesions (3/15 and 2/15 rats), with 11 rats showing no adhesions in one model. Histologic analysis indicated accelerated healing in Group 3.
Conclusions:
- Fibrin glue is effective in inhibiting intra-abdominal adhesion formation in rats.
- The anti-adhesion effect of fibrin glue is dose-dependent on fibrinogen concentration.
- Fibrin glue reduces adhesions irrespective of peritoneal defect closure, suggesting a direct inhibitory mechanism.