Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 3, 2026

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

Berberine attenuates cardiac dysfunction in hyperglycemic and hypercholesterolemic rats.

Shi-Fen Dong¹, Ying Hong, Ming Liu

¹Department of Pharmacology, Beijing University of Chinese Medicine, Beijing 100029, China.

European Journal of Pharmacology

|April 5, 2011

Summary

Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Rotator cuff injury disrupts sleep architecture in mice and exhibits a light-dark phase-dependent pattern.

BMC musculoskeletal disorders·2026

Same author

The Changes in Synergistic Patterns of Peri-Shoulder Muscles During Shoulder Abduction and Flexion in Patients With Rotator Cuff Tears.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2025

Same author

Therapeutic efficacy of home-based neuromuscular electrical stimulation on early postoperative functional recovery following arthroscopic rotator cuff repair: a double-blind randomized controlled trial.

BMC musculoskeletal disorders·2025

Same author

Cognitive-behavioural physical therapy improves psychological readiness for return to sport, knee function, and resilience in patients after anterior cruciate ligament reconstruction: A randomised controlled trial.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2025

Same author

Does proprioceptive training improve joint function and psychological readiness in patients after anterior cruciate ligament reconstruction? A randomized controlled trial.

BMC musculoskeletal disorders·2025

Same author

An additional rehabilitation program to improve postoperative outcomes in patients with rotator cuff tear and scapular dyskinesis: a propensity score-matched study.

BMC musculoskeletal disorders·2025

Berberine effectively improved cardiac function in rats with hyperglycemia and hypercholesterolemia. This natural compound reduced blood sugar and lipids, protecting the heart by improving fatty acid and glucose transport.

Area of Science:

Cardiovascular Research
Metabolic Disorders
Pharmacology

Background:

Hyperglycemia and hypercholesterolemia significantly impair cardiac function.
Developing effective treatments for metabolic-induced cardiac dysfunction is crucial.

Purpose of the Study:

To evaluate the protective effects of berberine on cardiac dysfunction in a rat model of hyperglycemia and hypercholesterolemia.
To investigate the impact of berberine on cardiac lipid and glucose metabolism.

Main Methods:

A rat model was established using a high-sucrose/fat diet and streptozotocin injection.
Berberine (30 mg/kg/day) was administered for 6 weeks.
Cardiac function, plasma lipid/glucose levels, and key metabolic gene/protein expressions were assessed.

Related Experiment Videos

Last Updated: Jun 3, 2026

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

Main Results:

Berberine treatment significantly reduced plasma glucose, total cholesterol, and triglyceride levels.
Cardiac dysfunction markers were improved by berberine, with increases in cardiac output and contractility, and decreases in diastolic pressure.
Berberine modulated cardiac fatty acid transport and oxidation, and glucose transport, while altering PPAR expression.

Conclusions:

Berberine demonstrates significant cardioprotective effects against hyperglycemia and hypercholesterolemia-induced dysfunction.
The mechanism involves alleviating cardiac lipid accumulation and enhancing glucose transport.
Berberine shows potential as a therapeutic agent for metabolic-related cardiovascular diseases.