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Ghrelin in gastrointestinal disease
Penny Jeffery1, Victoria McDonald, Emma Tippett
1Mater Medical Research Institute, Mater Health Services, South Brisbane, Queensland 4101, Australia. pjeffery@mmri.mater.org.au
Ghrelin, a hormone primarily from the stomach, is affected by gastrointestinal diseases. Ghrelin and its analogs show promise in treating gut inflammation and motility issues.
Area of Science:
- Gastroenterology
- Endocrinology
- Pharmacology
Background:
- Ghrelin is predominantly produced by gastric enteroendocrine cells, but also found throughout the gastrointestinal tract.
- Gastrointestinal disorders can significantly alter ghrelin production and secretion.
- Ghrelin plays a role in regulating gastrointestinal functions.
Purpose of the Study:
- To review the impact of gastrointestinal diseases on ghrelin synthesis and secretion.
- To explore the therapeutic potential of ghrelin and its mimetics in treating gastrointestinal disorders.
Main Methods:
- Literature review of studies on ghrelin in gastrointestinal diseases.
- Analysis of animal studies and human clinical trials.
Main Results:
- Gastrointestinal diseases alter ghrelin levels and activity.
- Animal studies indicate ghrelin can reduce gastric and colonic inflammation.
- Human trials are investigating ghrelin for motility disorders.
Conclusions:
- Gastrointestinal diseases disrupt ghrelin homeostasis.
- Ghrelin and its mimetics represent a potential therapeutic strategy for gastrointestinal inflammatory and motility disorders.
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