The molecular biology of human herpesvirus-6 latency and telomere integration
Jesse H Arbuckle1, Peter G Medveczky
1Department of Molecular Medicine, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA.
Microbes and Infection
|April 5, 2011
Abstract:
The genomes of herpesviruses establish latency as a circular episome. However, Human herpesvirus-6 (HHV-6) has been shown to specifically integrate into the telomeres of chromosomes during latency and vertically transmit through the germ-line. This review will focus on the telomere integration of HHV-6, the potential viral and cellular genes that mediate integration, and the clinical impact on the host.
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