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[Prevention of progression and regression of target organ damage. Future strategies]

A de la Sierra1

  • 1Unidad de Hipertensión, Servicio de Medicina Interna, Hospital Mútua Terrassa, Universidad de Barcelona, Barcelona, Spain. adelasierra@mutuaterrassa.es

Revista Clinica Espanola
|April 5, 2011
PubMed

Insights

Renin-angiotensin system blockers benefit cardiovascular disease (CVD) by lowering blood pressure and reducing events. However, residual risk remains, necessitating further strategies for comprehensive CVD risk reduction.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Context:

  • Renin-angiotensin system (RAS) blockers, including ACE inhibitors and AT1 receptor antagonists, are established treatments for cardiovascular disease (CVD).
  • These agents demonstrate efficacy in lowering blood pressure, preventing microalbuminuria, reducing cardiovascular and renal events, and improving survival in various CVD stages.

Purpose:

  • To review strategies for reducing residual cardiovascular disease risk in patients treated with RAS blockers.
  • To explore additional therapeutic options beyond standard RAS blockade.

Summary:

  • RAS blockers offer significant benefits across CVD stages, from preventing subclinical markers to improving survival in advanced disease.
  • Despite benefits, a significant residual risk persists in patients on these therapies.
  • This review examines complementary approaches including primary prevention, intensified therapeutic targets, comprehensive risk factor management, enhanced RAS blockade, and synergistic drug mechanisms.

Impact:

  • Identifies key areas for improving patient outcomes in cardiovascular disease management.
  • Highlights the need for multifaceted strategies to further mitigate cardiovascular and renal risk.
  • Provides a framework for clinicians to optimize treatment regimens for patients with or at risk of CVD.

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