Florfenicol feed supplemented decrease the clinical effects of Mycoplasma hyopneumoniae experimental infection in
A Ciprián1, J M Palacios, D Quintanar
1Secretaria de Estudios de Posgrado, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Mexico. seme@servidor.unam.mx
Research in Veterinary Science
|April 5, 2011
Summary
Florfenicol feed supplementation improved weight gain and reduced lung lesions in pigs infected with Mycoplasma hyopneumoniae. This treatment offers potential benefits for managing swine respiratory disease.
Area of Science:
- Veterinary Medicine
- Animal Science
- Pharmacology
Background:
- Mycoplasma hyopneumoniae causes chronic respiratory infections in pigs, leading to significant economic losses.
- Swine respiratory disease complex impacts animal welfare and farm productivity.
- Effective therapeutic strategies are needed to mitigate the effects of M. hyopneumoniae.
Purpose of the Study:
- To evaluate the therapeutic efficacy of Florfenicol when administered via feed supplementation.
- To assess the impact of Florfenicol on clinical signs and pathological outcomes of Mycoplasma hyopneumoniae infection in pigs.
Main Methods:
- Conventional pigs (average 16 kg) were intratracheally inoculated with M. hyopneumoniae.
- Two groups were established: non-medicated control and Florfenicol-treated (20 g/ton feed) for 35 days.
- Evaluated average daily weight gain, pneumonic gross lesion extent, and M. hyopneumoniae colonization.
Main Results:
- Florfenicol-treated pigs showed significantly higher average daily weight gain (0.33 kg/day) compared to non-treated pigs (0.21 kg/day).
- Pneumonic lesion extent was reduced in Florfenicol-treated pigs (1.79%) versus non-treated pigs (13.99%).
- M. hyopneumoniae colonization was detected in both infected groups, but lesion severity was generally greater in non-medicated pigs.
Conclusions:
- Oral Florfenicol administration via feed supplementation demonstrated efficacy in ameliorating clinical effects of M. hyopneumoniae infection.
- Florfenicol treatment improved growth performance and reduced lung pathology associated with M. hyopneumoniae.
- Further research may optimize Florfenicol dosage and treatment duration for swine respiratory disease management.
