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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

[Clinical features and outcome of 2009 H1N1 influenza in the pediatric setting. Multicenter prospective study in the

C Desmoulins1, A-P Michard-Lenoir2, J Naud3

  • 1Service des urgences pédiatriques, université Paris Descartes, hôpital Necker-Enfants-Malades, 149, rue de Sèvres, 75015 Paris, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|April 5, 2011
PubMed

Insights

Young infants under three months are not at higher risk for 2009 H1N1 influenza complications. Oseltamivir treatment did not shorten symptom duration in pediatric patients.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Public Health

Context:

  • The 2009 H1N1 influenza pandemic posed a significant public health concern, particularly for vulnerable pediatric populations.
  • Understanding the clinical course and outcomes of H1N1 influenza in children is crucial for effective management and resource allocation.
  • Emergency departments serve as critical entry points for diagnosing and managing acute respiratory infections in children.

Purpose:

  • To describe the clinical manifestations and outcomes of infants and children diagnosed with 2009 H1N1 influenza in emergency departments.
  • To identify risk factors and complications associated with 2009 H1N1 influenza in pediatric patients.
  • To evaluate the impact of antiviral treatment on symptom duration.

Summary:

  • A prospective multicenter case series included 466 children with confirmed 2009 H1N1 influenza admitted to pediatric emergency departments.
  • Infants younger than three months and children with pre-existing chronic conditions (PECs) were analyzed separately.
  • Complication rates did not significantly differ between at-risk and non-at-risk children, although at-risk children experienced longer hospital stays.

Impact:

  • Findings indicate that infants under three months are not a high-risk group for influenza complications.
  • Oseltamivir treatment did not demonstrate a significant reduction in the duration of fever or cough in the studied pediatric population.
  • This study contributes to the understanding of H1N1 influenza epidemiology and clinical management in children, informing public health strategies.
Abstract

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