Related Experiment Video
Updated: Jun 3, 2026

Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants
Published on: July 29, 2019
Developmental toxicity and genotoxicity studies of wogonin
Li Zhao1, Zhen Chen, Qing Zhao
1Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, China.
Abstract:
We studied the developmental toxicities and genotoxic potency of a widely bioactive plant medicine-wogonin in vivo and in vitro. In the in vivo developmental experiments, high dose of wogonin (40mg/kg, intravenous injection) significantly induced the maternal weight gains and affected fetus including bodyweight, resorptions, live birth index and fetal skeletal alterations. In Ames test, no concentration-dependently increased TA98, TA100, and TA102 revertants were detected in wogonin groups whether in presence of metabolic activating enzymes or not. In the chromosome aberration test, wogonin dose-dependently increased structural chromosomal aberrations in CHL cells both with and without S9, even the effect was all judged (-). In micronucleus assay, no significant changes of MNPCE/PCE and PCE/NCE were found on mouse bone marrow micronucleus in wogonin groups. We concluded that wogonin induced developmental toxicities on pregnant mice and fetus, and the genotoxicities were positive. However no significant malformation was observed and only in vitro potency of chromosome aberration was weak, which suggested us wogonin could be a relatively safe drug in clinic.
More Related Videos
Related Concept Videos
Mutagenicity and Carcinogenicity
Toxicity Testing in Animals
Teratogenicity
In vitro Mutagenesis
In-vitro Mutagenesis
Drug Toxicity: Dose-Dependent Reactions

