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Elective regional lymph node dissection in malignant melanoma.

M Binder1, H Pehamberger, A Steiner

  • 1Department of Dermatology I, University of Vienna, Austria.

European Journal of Cancer (Oxford, England : 1990)
|January 1, 1990
PubMed
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Elective regional lymph node dissection (ELND) offers no significant survival benefit for stage I malignant melanoma patients. This study found similar outcomes for patients treated with wide local excision alone versus wide local excision plus ELND.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Dermatology

Background:

  • Malignant melanoma management involves surgical treatment decisions.
  • The role of elective regional lymph node dissection (ELND) in early-stage melanoma is debated.

Purpose of the Study:

  • To evaluate the prognostic impact of ELND in stage I malignant melanoma patients.
  • To compare survival rates between patients undergoing wide local excision (WLE) with and without ELND.

Main Methods:

  • Retrospective analysis of 168 stage I melanoma patients.
  • Comparison of survival between WLE alone (102 patients) and WLE plus ELND (66 patients).
  • Analysis stratified by Breslow depth and using Cox regression.

Main Results:

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  • No significant difference in 5-year (85.7% vs 89.1%) or 10-year (77.9% vs 73.1%) survival between the groups.
  • ELND did not significantly influence survival across different Breslow depth categories.
  • Cox regression analysis identified ELND as a non-significant prognostic factor.

Conclusions:

  • ELND is not recommended as a routine procedure for stage I malignant melanoma.
  • Treatment decisions should consider the lack of demonstrated survival benefit from ELND in this patient group.