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Updated: Jun 3, 2026

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
Published on: February 14, 2021
Chronic idiopathic inflammatory bowel diseases: the histology report
Matteo Cornaggia1, Monica Leutner, Claudia Mescoli
1Department of Laboratory Medicine, Pathology Unit, Clinica S. Carlo, Paderno Dugnano, Milano, Italy. cornaggia@clinicasancarlo.it
Abstract:
The incidence of chronic idiopathic inflammatory bowel diseases (IBD) is growing in western countries, making their histological diagnosis an everyday task for all pathologists. Reviews from the literature strongly suggest that such diagnosis cannot be performed on the histological ground alone but requires a clinical-pathological approach. Moreover, bewildering variations can be observed in the terminology employed to report either individual lesions or diagnostic categories. The aim of the present paper is to suggest a practical diagnostic algorithm summarizing the main data from the literature. Particular emphasis has been placed on minimum clinical information required and the accurate definition of individual lesions. Diagnostic categories to employ and to avoid in daily practice have furthermore been stressed.
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