Related Experiment Video
Updated: Jun 3, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
Published on: October 16, 2021
Bulging subaortic septum: an important risk factor for systolic anterior motion after mitral valve repair
Sameh M Said1, Hartzell V Schaff, Rakesh M Suri
1Division of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA.
Background:
The purpose of this study is to determine etiologic factors of systolic anterior motion (SAM) of the mitral valve after repair.
Methods:
We describe 6 patients with mitral valve repair (MVRep) for degenerative mitral valve disease and a bulging angulated subaortic septum that seemed a risk factor for SAM.
Results:
No patient had a hypertrophic cardiomyopathy diagnosis. All patients had an angulated septum (angle of long axis of left ventricle and aorta, >60°) with a discrete septal bulge (proximal septum, ≥1.5 cm with normal midseptal thickness). One patient had severe mitral regurgitation and became hypotensive intraoperatively, with a SAM. He had successful valve repair and septal myectomy. In 2 patients, the bulging septum was not appreciated preoperatively, and SAM developed postoperatively, causing symptomatic left ventricular (LV) outflow tract (LVOT) obstruction and recurrent mitral regurgitation. At reoperation, SAM and associated regurgitation were abolished with septal myectomy. In 2 patients undergoing mitral repair, bulging septum was identified preoperatively, and prophylactic septal myectomy was performed at valve repair. One patient was referred for valve replacement because of severe mitral regurgitation due to bileaflet prolapse and associated SAM. Doppler echocardiography showed minimal resting gradient. He had a prominent subaortic septum, and mitral regurgitation seemed due to organic valve disease and dynamic outflow obstruction. He received septal myectomy and mitral valve repair with resolution of SAM and mitral regurgitation.
Conclusions:
Bulging subaortic septum may be a risk factor for SAM after mitral valve repair. Treatment should include septal myectomy with valvuloplasty.
Insights
Systolic anterior motion (SAM) after mitral valve repair can be caused by a bulging subaortic septum. Septal myectomy alongside valve repair effectively treats this condition, improving outcomes.
Area of Science:
- Cardiovascular Surgery
- Cardiac Anatomy
- Echocardiography
Background:
- Systolic anterior motion (SAM) of the mitral valve is a potential complication following mitral valve repair (MVRep).
- Identifying etiologic factors for SAM is crucial for improving surgical outcomes.
Purpose of the Study:
- To determine the etiologic factors of systolic anterior motion (SAM) of the mitral valve after mitral valve repair.
- To investigate the role of a bulging angulated subaortic septum as a risk factor for SAM.
Main Methods:
- Retrospective analysis of 6 patients who underwent mitral valve repair for degenerative mitral valve disease.
- Detailed echocardiographic and intraoperative assessment of subaortic anatomy, including septal angulation and thickness.
- Evaluation of surgical interventions, including septal myectomy and valve repair/replacement.
Main Results:
- All patients exhibited an angulated septum (>60°) with a discrete septal bulge (≥1.5 cm).
- SAM developed postoperatively in some patients, causing left ventricular outflow tract (LVOT) obstruction and mitral regurgitation, successfully treated with septal myectomy.
- Prophylactic septal myectomy in conjunction with mitral repair prevented SAM development in other cases.
Conclusions:
- A bulging angulated subaortic septum is a significant risk factor for developing systolic anterior motion (SAM) after mitral valve repair.
- Surgical management should consider septal myectomy in conjunction with mitral valve repair or valvuloplasty to address this anatomical risk factor and prevent SAM.
Related Concept Videos
Mitral Stenosis I: Introduction
Mitral Valve Prolapse I: Introduction
Mitral Regurgitation I: Introduction
Mitral Valve Prolapse II: Assessment and Management
Mitral Stenosis III: Medical Management
Mitral Regurgitation II: Clinical Features and Diagnostic Tests
