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Related Experiment Video

Updated: Jun 3, 2026

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
09:09

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

Single plasmonic nanoparticles for biosensing.

Takumi Sannomiya1, Janos Vörös

  • 1Laboratory of Biosensors & Bioelectronics, ETH Zurich, Gloriastrasse 35, 8092 Zurich, Switzerland. sannomiya@biomed.ee.ethz.ch

Trends in Biotechnology
|April 5, 2011
PubMed
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Single plasmonic nanoparticle sensors offer ultrasensitive detection of single biomolecules, enabling new insights into molecular behavior. Future applications include high-throughput diagnostics and drug discovery through massive multiplexing.

Area of Science:

  • Nanoplasmonics
  • Biosensing
  • Molecular diagnostics

Background:

  • Nanoparticle sensors are comparable in size to biomolecules.
  • Single particle sensing methods have advanced significantly.
  • Recent progress in nanoplasmonics enables new sensing capabilities.

Purpose of the Study:

  • To review recent achievements in single plasmonic nanoparticle biosensing.
  • To discuss the perspectives of this emerging biosensing technique.
  • To highlight the potential for massive multiplexing in diagnostics and drug discovery.

Main Methods:

  • Detection of single biomolecule adsorption.
  • Analysis of single molecule conformational changes.
  • Development of compact sensor units for arrays.

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Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations
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Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations

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Related Experiment Videos

Last Updated: Jun 3, 2026

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
09:09

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
09:13

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations
06:19

Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations

Published on: June 23, 2022

Main Results:

  • Demonstrated detection of single biomolecule adsorption.
  • Provided insights into single molecule conformational changes.
  • Established the foundation for massive multiplexing in biosensing.

Conclusions:

  • Single plasmonic nanoparticle sensors represent a significant advancement in biosensing.
  • Arrays of these sensors are poised for high-throughput applications in diagnostics and drug discovery.
  • This technology offers a new dimension in sensing scale and molecular analysis.