The immunohistochemical profile of oral inflammatory myofibroblastic tumors
Fernanda Salgueiredo-Giudice1, Felipe Fornias-Sperandio, Erika Martins-Pereira
1Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil. fernandagiudice@usp.br
Objective:
The aim of this study was to demonstrate the immunohistochemical profile of oral inflammatory myofibroblastic tumors (IMTs) along with morphologic analysis.
Study Design:
Three cases diagnosed as oral IMTs were selected to compile an immunohistochemical panel constituted by calponin, caldesmon, Bcl-2, desmin, fibronectin, CD68, Ki-67, S100, anaplastic lymphoma kinase (ALK), α-smooth muscle actin, cytokeratins AE1/AE3, muscle-specific actin, CD34, and vimentin. An oral squamous cell carcinoma with a focal area of desmoplastic stroma was used as control for the stained myofibroblastic cells.
Results:
All oral IMTs were positive for calponin, revealing a strong and diffuse expression in the spindle-shaped cells. The lesions were also positive for vimentin (3/3), fibronectin (3/3), α-smooth muscle actin (3/3), and muscle-specific actin (1/3) and negative for h-caldesmon, Bcl-2, desmin, CD68, Ki-67, S100, ALK, cytokeratins AE1/AE3, and CD34.
Conclusions:
Within the results encountered, the present panel should be of great assistance in the diagnosis of oral IMTs.
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