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Prevalence of hepatitis B and C in HIV-infected patients: a meta-analysis

Jia-Jia Chen1, Cheng-Bo Yu, Wei-Bo Du

  • 1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Hepatobiliary & Pancreatic Diseases International : HBPD INT
|April 5, 2011
PubMed

Insights

Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) coinfection is more common than hepatitis B virus (HBV) and HIV coinfection. However, HCV infection does not impact HBV prevalence in HIV patients.

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • Hepatitis C virus (HCV), hepatitis B virus (HBV), and human immunodeficiency virus (HIV) share transmission routes.
  • Coinfection among these viruses is common due to similar transmission pathways like sexual contact and parenteral injection.
  • This study focuses on the prevalence of HCV or HBV coinfection in individuals with HIV.

Purpose of the Study:

  • To determine the prevalence of coinfection with either HCV or HBV in patients diagnosed with HIV.
  • To compare the rates of HCV-HIV coinfection versus HBV-HIV coinfection.
  • To investigate the impact of HCV infection on HBV prevalence in HIV-positive individuals.

Main Methods:

  • A meta-analysis was conducted to quantify HBV coinfection with HCV in HIV patients.
  • Searched PubMed, ISI Web of Science, Cochrane Library, CNKI, and Google Scholar for English and Chinese studies before November 2009.
  • Utilized keywords: hepatitis C, HCV, hepatitis B, HBV, human immunodeficiency virus, HIV, and coinfection. RevMan 5.0 software was used for analysis.

Main Results:

  • Identified 22 studies with 17,664 patients.
  • HCV coinfection with HIV was significantly more prevalent than HBV coinfection with HIV (OR=3.00; 95% CI 1.90-4.73).
  • Subgroup analysis revealed regional differences, particularly between European, Asian, and African cohorts. No significant difference in HBV prevalence was found between HIV+HBV+HCV+ and HIV+HBV+HCV- patients (OR=0.91; 95% CI 0.57-1.45).

Conclusions:

  • HCV-HIV coinfection is overall more frequent than HBV-HIV coinfection.
  • HCV infection does not appear to affect the prevalence of HBV infection in HIV-positive patients.
  • Regional variations in coinfection patterns exist among HIV-positive populations.
Abstract

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