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Genome sequences of Mycoplasma alligatoris A21JP2T and Mycoplasma crocodyli MP145T

D R Brown1, W G Farmerie, M May

  • 1Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA. drbrown@ufl.edu

Journal of Bacteriology
|April 5, 2011
PubMed

Insights

Mycoplasma alligatoris causes severe disease, unlike its close relative Mycoplasma crocodyli. Genomic analysis revealed unique sialidase genes in M. alligatoris, potentially explaining its high virulence.

Area of Science:

  • Microbiology
  • Genomics
  • Veterinary Science

Background:

  • Mycoplasma alligatoris and Mycoplasma crocodyli are closely related species.
  • M. alligatoris exhibits high virulence, while M. crocodyli is relatively attenuated.
  • Understanding virulence factors in closely related species is crucial for disease control.

Purpose of the Study:

  • To compare the genomes of M. alligatoris and M. crocodyli.
  • To identify genetic factors contributing to M. alligatoris' high virulence.
  • To investigate the evolutionary origins of virulence in this mycoplasma clade.

Main Methods:

  • Whole-genome sequencing of M. alligatoris and M. crocodyli.
  • Comparative genomic analysis.
  • Identification and characterization of specific gene pathways.

Main Results:

  • The M. alligatoris genome, though incomplete, showed significant differences from M. crocodyli.
  • M. alligatoris possesses an expanded complement of sialidase genes.
  • Genes involved in N-acetylneuraminate scavenging and catabolism were notably different.

Conclusions:

  • The unique sialidase gene repertoire in M. alligatoris is a key differentiator from its less virulent relatives.
  • These genes likely play a significant role in the pathogenesis and high virulence of M. alligatoris.
  • Genomic comparison provides insights into the evolution of virulence within the Mycoplasma genus.

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