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Published on: November 5, 2020
Fiber intake and pancreatic cancer risk: a case-control study
E Bidoli1, C Pelucchi2, A Zucchetto1
1Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, Aviano.
Summary
Higher intake of total dietary fiber, particularly soluble and insoluble fiber like cellulose and lignin, is associated with a reduced risk of pancreatic cancer. Fruit fiber also showed a protective effect.
Area of Science:
- Oncology
- Nutritional Epidemiology
- Gastroenterology
Background:
- Limited research exists on the link between dietary fiber and pancreatic cancer.
- A case-control study was conducted in Northern Italy to address this knowledge gap.
Purpose of the Study:
- To investigate the association between various types of dietary fiber and pancreatic cancer risk.
- To clarify the role of fiber in pancreatic cancer etiology.
Main Methods:
- A case-control study involving 326 pancreatic cancer patients and 652 controls.
- Dietary intake assessed using a validated food frequency questionnaire.
- Odds ratios (ORs) calculated for fiber intake quintiles, adjusting for energy and confounders.
Main Results:
- Total dietary fiber intake showed an inverse relationship with pancreatic cancer risk (OR=0.4).
- Soluble fiber (OR=0.4) and insoluble fiber, especially cellulose (OR=0.4) and lignin (OR=0.5), were associated with lower risk.
- Fruit fiber intake was inversely associated (OR=0.5), but grain fiber was not (OR=1.2).
Conclusions:
- Selected types of dietary fiber, including total fiber, are inversely related to pancreatic cancer.
- Specific fiber components like soluble, insoluble, cellulose, and lignin may play a protective role.
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