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Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
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Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

Lysozyme expression in microscopic colitis.

Carlos A Rubio1

  • 1Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden. carlos.rubio@ki.se

Journal of Clinical Pathology
|April 5, 2011
PubMed
Summary
This summary is machine-generated.

Microscopic colitis, including collagenous colitis (CC) and lymphocytic colitis (LC), shows increased lysozyme production, suggesting a bacterial cause. Lysozyme expression differs between CC and LC, indicating distinct disease mechanisms.

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Cryosectioning Method for Microdissection of Murine Colonic Mucosa
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Last Updated: Jun 3, 2026

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

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Published on: January 5, 2017

Cryosectioning Method for Microdissection of Murine Colonic Mucosa
06:16

Cryosectioning Method for Microdissection of Murine Colonic Mucosa

Published on: July 12, 2015

Area of Science:

  • Gastroenterology
  • Immunology
  • Pathology

Background:

  • Microscopic colitis (MC) encompasses collagenous colitis (CC) and lymphocytic colitis (LC).
  • The role of bacterial infections in MC pathogenesis is debated.
  • Lysozyme, an innate antibacterial enzyme, plays a crucial role in mucosal defense.

Purpose of the Study:

  • To investigate the cellular expression of lysozyme in colonic biopsies from patients with microscopic colitis (MC).
  • To compare lysozyme expression in MC with that in inflammatory bowel disease (IBD) of the colon (ulcerative colitis [UC] and Crohn's colitis).

Main Methods:

  • Biopsies from 55 patients (27 MC: 14 CC, 13 LC; 28 IBD: 14 UC, 14 Crohn's colitis) were analyzed.
  • Immunohistochemistry was performed using antilysozyme antibody.
  • CD68 staining was used to identify macrophages in a subset of cases.

Main Results:

  • Marked lysozyme expression was observed in colonic crypts of CC patients (p<0.05).
  • Metaplastic Paneth cells were more frequent in CC than LC (p<0.05).
  • Lysozyme expression was noted in macrophages in LC (LC vs CC, p<0.05), while active Crohn's colitis showed cryptal lysozyme.

Conclusions:

  • Increased lysozyme production in CC and LC suggests a bacterial etiology for these conditions.
  • Differential lysozyme expression in epithelial cells versus macrophages indicates that CC and LC may represent distinct disease entities.