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Patterns of ciprofloxacin-resistant gram-negative bacteria colonization in nursing home residents

Parimala Dommeti1, Linda Wang, Erika L Flannery

  • 1Division of Geriatric Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Infection Control and Hospital Epidemiology
|April 5, 2011
PubMed

Insights

Nursing home residents with indwelling devices face higher risks of colonization by gram-negative bacilli (GNB), including ciprofloxacin-resistant strains. Reduced functional status further elevates the risk of acquiring these resistant GNB.

Area of Science:

  • Infectious Diseases
  • Gerontology
  • Microbiology

Background:

  • Nursing home residents are susceptible to infections, particularly those with indwelling devices.
  • Gram-negative bacilli (GNB) are common causes of healthcare-associated infections.
  • Antibiotic resistance, especially to fluoroquinolones like ciprofloxacin, is a growing concern in long-term care facilities.

Purpose of the Study:

  • To determine the prevalence of colonization with all GNB and ciprofloxacin-resistant GNB in nursing home residents.
  • To investigate the association between indwelling devices and GNB colonization.
  • To examine the relationship between functional status and colonization with ciprofloxacin-resistant GNB.

Main Methods:

  • Cross-sectional study evaluating GNB colonization in nursing home residents.
  • Comparison between residents with and without indwelling devices (e.g., urinary catheters, feeding tubes).
  • Assessment of resident functional status using a standardized scale.

Main Results:

  • Indwelling device presence was significantly associated with increased colonization by all GNB.
  • Residents with indwelling devices also showed a higher prevalence of ciprofloxacin-resistant GNB colonization.
  • A negative correlation was observed between functional status and colonization with ciprofloxacin-resistant GNB, indicating higher risk with poorer function.

Conclusions:

  • Indwelling devices are a critical risk factor for GNB colonization, including resistant strains, in nursing home residents.
  • Functional status is an independent risk factor for acquiring ciprofloxacin-resistant GNB.
  • Strategies to minimize device use and improve infection control are crucial in nursing homes.

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