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Related Experiment Videos

Multifocal fixed drug eruption mimicking erythema multiforme.

J M Sowden1, A G Smith

  • 1Department of Dermatology, North Staffordshire Hospital Centre, Stoke-on-Trent, UK.

Clinical and Experimental Dermatology
|September 1, 1990
PubMed
Summary

A woman experienced recurrent bullous eruptions linked to menstruation. Initially suspected as autoimmune progesterone dermatitis, investigations revealed a fixed drug eruption to mefenamic acid.

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Recurrent bullous eruptions can present diagnostic challenges.
  • Dysmenorrhea management sometimes involves hormonal therapies or NSAIDs.

Observation:

  • A 38-year-old woman developed a widespread bullous eruption.
  • The eruption recurred cyclically with menstruation.
  • Initial skin biopsy suggested erythema multiforme.

Findings:

  • Autoimmune progesterone dermatitis was considered due to cyclical recurrence and progesterone use.
  • Subsequent investigations ruled out autoimmune progesterone dermatitis.
  • The eruption was confirmed as a fixed drug eruption to mefenamic acid, an NSAID used for dysmenorrhea.

Implications:

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  • Highlights the importance of thorough drug history in diagnosing recurrent dermatological conditions.
  • Mefenamic acid should be considered as a potential cause of fixed drug eruptions, especially with cyclical patterns.
  • Distinguishing fixed drug eruptions from other cyclical dermatoses is crucial for appropriate patient management.