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Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
Drug-coated balloons in the lower limb
T Zeller1, S Schmitmeier, G Tepe
1Angiology Division, Heart Center, Bad Krozingen, Germany. thomas.zeller@herzzentrum.de
The Journal of Cardiovascular Surgery
|April 5, 2011
Summary
Drug-coated balloons offer promising results for femoro-popliteal artery lesions, showing improved patency compared to standard angioplasty. This stentless technology is an attractive alternative for peripheral artery disease treatment.
Area of Science:
- Vascular surgery
- Interventional cardiology
- Biomaterials science
Background:
- Concerns persist regarding stent implantation in the femoro-popliteal artery.
- Stentless technologies achieving comparable or superior results are highly desirable.
- Paclitaxel-eluting stents have shown recent positive outcomes but concerns remain.
Purpose of the Study:
- To evaluate the efficacy of drug-coated balloons (DCBs) in femoro-popliteal lesions.
- To compare DCB outcomes with plain balloon angioplasty and bare metal stents.
- To provide an overview of ongoing trials involving DCBs in peripheral arteries.
Main Methods:
- Review of randomized studies (THUNDER, FEMPAC, LEVANT 1) on paclitaxel-releasing DCBs.
- Analysis of data from ongoing trials evaluating DCBs below the knee (PICCOLO study).
- Inclusion of presented data on drug-eluting stents for shorter lesions (YUKON BTK, DESTINY).
Main Results:
- DCBs demonstrated significantly improved patency rates in femoro-popliteal lesions versus plain balloon angioplasty.
- DCB patency results were comparable to those of most bare metal nitinol stents.
- The efficacy of DCBs below the knee is still under evaluation.
Conclusions:
- Drug-coated balloons represent a promising stentless technology for femoro-popliteal artery revascularization.
- DCBs offer a viable alternative to stenting, with favorable patency rates.
- Further evaluation of DCBs, especially below the knee, is ongoing.
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