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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Lipoprotein(a) in the arterial wall
U Beisiegel1, A Niendorf, K Wolf
1Medizinische Kernklinik und Poliklinik, Universitätskrankenhaus Eppendorf, Hamburg, F.R.G.
European Heart Journal
|August 1, 1990
Summary
Lipoprotein(a) [Lp(a)] is confirmed as an independent risk factor for coronary heart disease (CHD). Lp(a) accumulates in arterial walls, particularly in plaque areas, and co-localizes with apo B and fibrin, suggesting a mechanism for its role in CHD.
Area of Science:
- Cardiovascular Biology
- Lipid Metabolism
- Atherosclerosis Research
Background:
- Coronary heart disease (CHD) remains a leading cause of mortality worldwide.
- Lipid(a) [Lp(a)] is a lipoprotein particle implicated in cardiovascular risk.
- The precise mechanisms by which Lp(a) contributes to CHD pathogenesis require further elucidation.
Purpose of the Study:
- To confirm the role of Lp(a) as an independent risk factor for CHD.
- To investigate the biochemical and immunohistochemical mechanisms underlying Lp(a)-induced CHD.
- To analyze the localization and distribution of Lp(a) within human arterial walls.
Main Methods:
- Comparison of Lp(a) levels in CHD patients versus healthy blood donors.
- Biochemical and immunohistochemical analysis of human arterial wall biopsies and autopsy tissues.
- Density gradient ultracentrifugation to analyze lipoprotein fractions from arterial walls.
- Immunohistochemical localization of apo(a), apo B, and fibrin in different vessel areas.
Main Results:
- Lp(a) concentration in arterial intima correlates with serum Lp(a) levels.
- Lp(a) preferentially accumulates in atherosclerotic plaque areas.
- Significant co-localization of apo(a) with apo B and fibrin was observed within the arterial wall.
- Apo(a) was also detected within foam cells in the arterial wall.
Conclusions:
- Lp(a) plays a significant role as an independent risk factor in the development of CHD.
- Lp(a) accumulates within the arterial intima, particularly in atherosclerotic plaques.
- The co-localization with apo B and fibrin suggests potential mechanisms involving lipoprotein metabolism and thrombosis in Lp(a)-mediated atherogenesis.
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