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Characterization of antiphospholipid antibodies in chronic hepatitis B infection

Ji Young Huh1, Dae Young Yi, Seong Gyu Hwang

  • 1Department of Laboratory Medicine, CHA Bundang Medical Center, Seongnam, Korea.

The Korean Journal of Hematology
|April 5, 2011
PubMed

Insights

Antiphospholipid antibodies (aPLs) were found in 12.6% of hepatitis B virus (HBV)-infected patients, primarily as IgM anticardiolipin antibodies (aCL Ab). Most aPLs persisted for 12 weeks, showing a weak association with Antiphospholipid Syndrome (APS) clinical manifestations.

Area of Science:

  • Immunology
  • Hepatology
  • Infectious Diseases

Background:

  • Infections are frequently linked to antiphospholipid antibodies (aPLs).
  • Hepatitis B virus (HBV) infection is a common global health concern.

Purpose of the Study:

  • To determine the prevalence, persistence, clinical significance, and characteristics of aPLs in HBV-infected patients.
  • To investigate the association between aPLs and clinical manifestations in HBV infection.

Main Methods:

  • Assessed anticardiolipin antibodies (aCL Ab), anti-β(2)-glycoprotein I antibodies (β(2)GPI Ab), and lupus anticoagulant (LA) in 143 HBV patients and 32 controls.
  • Follow-up specimens were collected from patients with elevated aPL levels.

Main Results:

  • A total of 12.6% of HBV patients tested positive for aPLs, predominantly IgM aCL Ab.
  • Persistent aPLs were observed in 71.4% of patients over a 12-week period.
  • No significant clinical manifestations related to aPLs were identified in the study cohort.

Conclusions:

  • IgM aCL Ab were the most common aPLs in HBV infection, with a weak link to Antiphospholipid Syndrome (APS) clinical features.
  • Unlike transient aPLs in other infections, aPLs in HBV patients demonstrated persistent detection over 12 weeks.
  • The findings highlight the distinct profile of aPLs in HBV infection, emphasizing their persistence rather than transient presence.
Abstract

Keywords:
Anti-β2-glycoprotein I antibodiesAnticardiolipin antibodiesHepatitis B virusLupus coagulation inhibitor

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