Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cystic ovarian disease in dairy cattle: Diagnostic accuracy when using B-mode and color Doppler ultrasound.

Journal of dairy science·2023
Same author

Neuropathological and biochemical investigation of Hereditary Ferritinopathy cases with ferritin light chain mutation: Prominent protein aggregation in the absence of major mitochondrial or oxidative stress.

Neuropathology and applied neurobiology·2020
Same author

Trichloroethylene and its metabolite TaClo lead to degeneration of substantia nigra dopaminergic neurones: Effects in wild type and human A30P mutant α-synuclein mice.

Neuroscience letters·2019
Same author

Heterogeneity in α-synuclein subtypes and their expression in cortical brain tissue lysates from Lewy body diseases and Alzheimer's disease.

Neuropathology and applied neurobiology·2018
Same author

Determination of mycotoxins, alkaloids, phytochemicals, antioxidants and cytotoxicity in Asiatic ginseng (Ashwagandha, Dong quai, <i>Panax ginseng</i>).

Chemicke zvesti·2017
Same author

Exome sequencing in dementia with Lewy bodies.

Translational psychiatry·2016
Same journal

Rehabilitation Utilization for Parkinson's Disease in Southern Ghana: A Descriptive Cross-Sectional Survey.

Parkinson's disease·2026
Same journal

Dynamic Changes in Midbrain-Striatal Association and Their Relationship With Levodopa-Induced Dyskinesia in Parkinson's Disease.

Parkinson's disease·2026
Same journal

Acupuncture-Related Therapies as a Potential Adjuvant Option for Parkinson's Disease: Effects on Symptom Management, Medication Use, and Mortality.

Parkinson's disease·2026
Same journal

Early Amyloid Formation and Neuroinflammatory Response in a Bigenic Mouse Model Expressing Human α-Synuclein and Aβ.

Parkinson's disease·2026
Same journal

ICF-Based Assessment of Functioning Problems in Parkinson's Disease: Findings From a Cross-Sectional Survey in Southern Ghana.

Parkinson's disease·2026
Same journal

Identification of Gene Signatures and Molecular Mechanisms for Diagnosing Parkinson's Disease and Nonalcoholic Fatty Liver Disease Using Machine Learning.

Parkinson's disease·2026
See all related articles

Related Experiment Video

Updated: Jun 3, 2026

Histological Examination of Mitochondrial Morphology in a Parkinson's Disease Model
06:07

Histological Examination of Mitochondrial Morphology in a Parkinson's Disease Model

Published on: June 23, 2023

Mitochondrial dysfunction in Parkinson's disease.

P C Keane1, M Kurzawa, P G Blain

  • 1Medical Toxicology Centre, Wolfson Unit, Newcastle University, Claremont Place, Newcastle upon Tyne NE2 4AA, UK.

Parkinson'S Disease
|April 5, 2011
PubMed
Summary
This summary is machine-generated.

Mitochondrial dysfunction is strongly linked to Parkinson's disease (PD) pathogenesis. This review highlights evidence connecting impaired mitochondrial function and neuronal death in PD, emphasizing the need for further research.

More Related Videos

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
08:19

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry

Published on: May 5, 2022

Related Experiment Videos

Last Updated: Jun 3, 2026

Histological Examination of Mitochondrial Morphology in a Parkinson's Disease Model
06:07

Histological Examination of Mitochondrial Morphology in a Parkinson's Disease Model

Published on: June 23, 2023

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
08:19

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry

Published on: May 5, 2022

Area of Science:

  • Neuroscience
  • Cell Biology
  • Genetics

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder.
  • Mitochondrial dysfunction and electron transport chain inhibition are increasingly implicated in PD.
  • This dysfunction generates reactive oxygen species and depletes cellular energy, leading to neuronal damage.

Purpose of the Study:

  • To review the evidence linking mitochondrial dysfunction to neuronal cell death in Parkinson's disease.
  • To emphasize the role of mitochondria in the substantia nigra pars compacta (SNpc) in PD.

Main Methods:

  • Review of existing scientific literature.
  • Analysis of genetic links to inherited PD.
  • Examination of environmental toxin associations with PD.

Main Results:

  • Genetic studies show links between PD and mitochondrial proteins.
  • Environmental toxins inhibiting mitochondrial respiration are associated with PD.
  • Evidence supports mitochondrial dysfunction as a key factor in SNpc neuronal death in PD.

Conclusions:

  • Mitochondrial dysfunction is a significant contributor to neuronal cell death in Parkinson's disease.
  • Further research into mitochondrial pathways is crucial for understanding and treating PD.