Association between the CCR2-Val64Ile polymorphism and susceptibility to HIV-1 infection: a meta-analysis

Several studies have investigated whether the CCR2-Val64Ile polymorphism affects susceptibility to human immune deficiency virus type-1 (HIV-1), with inconclusive results. Here, we performed a meta-analysis of the literature aiming to clarify the relationship between the polymorphism of CCR2-Val64Ile and the risk of HIV-1 infection. Twelve studies with a total of 6,599 patients, including infants, were selected for inclusion in the analysis. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were assessed after the collected data were pooled for analysis. The risk estimates (OR) of HIV-1 infection were calculated in a homozygote comparison (OR=1.10, 95% CI 0.79-1.53), a heterozygote comparison (OR=0.98, 95% CI 0.70-1.37), a dominant model (OR=1.06, 95% CI 0.77-1.47) and a recessive model (OR=0.98, 95% CI 0.77-1.27, by random effects model) from among the total population. Taking into account the effect of sample size, ethnicity and control population, further stratified analyses were performed. The results showed no statistically significant difference in any genetic model, with the exception of the sub-analysis of mixed ethnicity (OR=0.33, 95% CI 0.11‑0.98) using heterozygote comparison. The meta-analysis clarified that the CCR2-Val64Ile polymorphism has no effect on susceptibility to HIV-1 infection in the total population.