Related Experiment Video

Updated: Jun 3, 2026

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
06:33

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Published on: June 9, 2018

QT dispersion in amyloidosis due to familial Mediterranean fever

Udi Nussinovitch1, Naomi Nussinovitch, Moshe Nussinovitch

  • 1The Heller Institute of Medical Research, and Department of Medicine F, Sheba Medical Center, Tel Hashomer Israel and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. enussi@yahoo.com

Rheumatology International
|April 5, 2011
PubMed

Insights

Familial Mediterranean fever (FMF) with amyloidosis did not show increased QT or JT dispersion compared to healthy individuals. This suggests repolarization dispersion may not be a significant marker in FMF-associated amyloidosis.

Area of Science:

  • Cardiology
  • Genetics
  • Internal Medicine

Background:

  • Cardiac amyloid deposition is a potential complication of familial Mediterranean fever (FMF).
  • QT dispersion (QTd) is a recognized marker for cardiac arrhythmias.
  • Previous studies suggest a link between amyloidosis and increased QTd.

Purpose of the Study:

  • To investigate repolarization dispersion in patients with familial Mediterranean fever (FMF) and amyloidosis.
  • To compare electrocardiographic findings between FMF-amyloidosis patients and healthy controls.

Main Methods:

  • 12-lead electrocardiography was performed on 18 FMF-amyloidosis patients and 18 age/sex-matched controls.
  • Repolarization and dispersion parameters, including QTd and JT dispersion, were computed using specialized software.
  • Averaging of 5 beats was used for parameter calculation.

Main Results:

  • No statistically significant differences were observed in average corrected QT interval, average QTd, QT dispersion ratio, JT dispersion, or JT corrected dispersion between the FMF-amyloidosis group and the control group.
  • Both groups exhibited similar repolarization and dispersion parameters.

Conclusions:

  • Patients with FMF-amyloidosis appear to have similar QT and JT dispersion parameters to healthy subjects.
  • Further research and extended follow-up are needed to determine the prognostic value of repolarization dispersion in FMF-associated amyloidosis.

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...