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Published on: October 27, 2014
Refractory generalized seizures as a possible side effect of bevacizumab in a colon cancer patient
Veli Berk1, Sevda Ismailogullari, Halil Donmez
1Department of Medical Oncology, Erciyes University Medical School, 38039 Kayseri, Turkey. veliberk@gmail.com
Abstract:
Bevacizumab, which is a humanized monoclonal antibody against vascular endothelial growth factor, is used to treat metastatic cancers of the colon. Adverse effects common with bevacizumab treatment are hypertension, arterial-venous thrombosis, bleeding, gastrointestinal perforation, and proteinuria. To date, there have been no reports of refractory seizure following treatment with bevacizumab. We describe a patient who presented with refractory generalized tonic-clonic seizures after receiving last dose of bevacizumab for treatment of metastatic colorectal cancer with FOLFIRI and bevacizumab regimen.
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