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Related Experiment Video

Updated: Jun 3, 2026

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
13:04

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

[Tissue engineering of vascular prostheses].

B H Walpoth1, M Möller

  • 1Departement für Herz- und Gefässchirurgie, Medizinische Fakultät, Universitätsspital Genf, Rue Gabrielle-Perret-Gentile 4, Genf, Switzerland. beat.walpoth@hcuge.ch

Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|April 5, 2011
PubMed
Summary
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Vascular tissue engineering offers a promising solution for replacing damaged blood vessels. An acellular, biodegradable scaffold shows potential for creating effective, ready-to-use vascular prostheses.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Materials Science

Context:

  • Current synthetic vascular prostheses face high failure rates, particularly in small-diameter applications, due to thrombosis and intimal hyperplasia.
  • Existing cell-based tissue-engineered grafts are often delayed, labor-intensive, and costly.
  • The need for improved vascular grafts drives research into novel biomaterials and engineering strategies.

Purpose:

  • To evaluate an acellular, biodegradable, electrospun scaffold for vascular tissue engineering.
  • To assess the efficacy of this approach for arterial replacement in animal models.

Summary:

  • An acellular vascular graft was developed using a biodegradable, electrospun, porous 3-D scaffold made of polycaprolactone fibers.
  • Animal studies in rats and pigs demonstrated successful arterial replacement with significant cellular and matrix ingrowth, angiogenesis, and endothelialization.

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Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent In Vivo Monitoring
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Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent In Vivo Monitoring

Published on: April 3, 2015

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method
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Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method

Published on: March 27, 2017

Related Experiment Videos

Last Updated: Jun 3, 2026

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
13:04

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent In Vivo Monitoring
11:17

Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent In Vivo Monitoring

Published on: April 3, 2015

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method
09:38

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method

Published on: March 27, 2017

  • The prostheses showed no signs of occlusion or aneurysm formation in both short and long-term follow-ups.

    • Impact:

    • This in vivo vascular tissue engineering approach yields shelf-ready, biodegradable vascular prostheses.
    • The findings suggest a viable alternative for future clinical applications in vascular reconstruction.
    • The acellular strategy overcomes limitations associated with cell-based grafts, offering a potentially more accessible solution.