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Published on: August 14, 2019
Two new 5,8-quinoflavans from the leaf of Ilex centrochinensis
Lu-Jun Li1, Yue Zhang, Peng Zhang
1Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, China.
Abstract:
Two new 5,8-quinoflavans were isolated from the leaf of Ilex centrochinensis, and their structures were elucidated as (2R)-7,3',4'-trimethoxy-5,8-quinoflavan and (2S)-7-methoxy-4'-hydroxy-5,8-quinoflavan on the basis of spectroscopic methods, especially 1D and 2D NMR, CD, and mass spectral analyses. Both of them exhibited weak cytotoxic activity against HuH7 cell lines and no cytotoxic activity against CaCO-2 cell lines.
