Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunoglobulin lambda light chain evolution: Igl and Igl-like sequences form three major groups.

D J Hayzer1

  • 1Department of Medical Biochemistry, Faculty of Medicine, University Medical Center, Geneva, Switzerland.

Immunogenetics
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strategies for the design of novel thrombolytic and antithrombolytic agents.

Trends in cardiovascular medicine·2011
Same author

cDNAs encoding the baboon thrombin receptor indicate a primate transcription start site upstream of putative sites reported for the human gene.

Thrombosis research·2000
Same author

Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor.

The Journal of biological chemistry·1997
Same author

The effect of edelfosine on CTP:cholinephosphate cytidylyltransferase activity in leukemic cell lines.

Leukemia research·1996
Same author

Insulin-like growth factor 1 binding protein 3 synthesis by aortic endothelial cells is a function of cell density.

Biochemical and biophysical research communications·1996
Same author

Alternative splicing of the mRNA encoding baboon glycoprotein receptor GPIIb.

Gene·1994
Same journal

Genotype-phenotype correlations in autoimmune and autoinflammatory diseases: An NGS-based immunogenetic cohort study.

Immunogenetics·2026
Same journal

Elevated interleukin-36γ and gene polymorphisms implicate novel risk in essential hypertension.

Immunogenetics·2026
Same journal

Unraveling the genomic structures, conserved functional domains and evolutionary dynamics of beta-defensins in Bubalus bubalis and Ovis aries.

Immunogenetics·2026
Same journal

Genetic characterization of the TAPBP and its allelic association with BF2 in the chicken major histocompatibility complex.

Immunogenetics·2026
Same journal

Reconstructed amphibian heavy-chain constant regions support a mosaic origin of IgXA with IgY-like CH1-CH2, an intermediate CH3, and an IgM-like CH4.

Immunogenetics·2026
Same journal

Climate factors and selection shape MHC class II diversity in a montane wild sheep (Ovis ammon).

Immunogenetics·2026
See all related articles

This study classifies immunoglobulin (Ig) Igl and Igl-like VpreB genes into three groups based on sequence comparisons. Evolutionary analysis reveals distinct evolutionary rates among these groups, suggesting independent gene duplication events in mammals.

Area of Science:

  • Immunology
  • Molecular Biology
  • Evolutionary Genetics

Background:

  • Immunoglobulin (Ig) genes are crucial for adaptive immunity.
  • Understanding the diversity and evolution of Ig genes, including Igl and Igl-like VpreB, is essential for deciphering immune system development and function.

Purpose of the Study:

  • To classify immunoglobulin (Ig) Igl and Igl-like VpreB gene sequences.
  • To analyze the evolutionary relationships and rates of different Ig gene groups.
  • To investigate the evolutionary history of Ig gene clusters in mammals.

Main Methods:

  • Sequence alignment and comparison of nucleotide and protein sequences of Ig Igl, Igl-like VpreB, and Igl-C genes.
  • Phylogenetic analysis to determine evolutionary relationships.

Related Experiment Videos

  • Comparative genomics to study gene cluster evolution.

    • Main Results:

    • A three-group classification (I, II, III) of Igl and Igl-like VpreB sequences was proposed.
    • Group III genes exhibit a faster evolutionary rate, with a further subdivision showing accelerated evolution in V lambda-encoding genes.
    • Ig Igl-J-C gene pair duplications appear to be species-specific events occurring after mammalian speciation.

    Conclusions:

    • All mammalian species likely possess Igl-V genes from each of the three identified groups.
    • The evolutionary dynamics of Ig genes vary significantly, with some lineages evolving faster than others.
    • Mammalian Ig gene cluster organization may differ, with mouse Igl-V-(J-C)(J-C) gene clusters potentially lacking direct homologues in other species.