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Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
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Published on: January 21, 2020

Syncope in complex regional pain syndrome.

Jason A Smith1, Dean G Karalis, Andrea L Rosso

  • 1Department of Cardiology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA. doctorjay21074@yahoo.com

Clinical Cardiology
|April 5, 2011
PubMed
Summary
This summary is machine-generated.

Syncope and presyncope are common in complex regional pain syndrome (CRPS). Lower limb involvement in CRPS patients increases the risk of these autonomic dysfunction symptoms, impacting diagnosis and treatment.

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Area of Science:

  • Neurology
  • Cardiology
  • Pain Medicine

Background:

  • Complex regional pain syndrome (CRPS) is a debilitating condition marked by severe pain and autonomic dysfunction.
  • Presyncope and syncope are frequently observed symptoms in patients with CRPS.

Purpose of the Study:

  • To investigate the underlying causes of presyncope and syncope in patients diagnosed with CRPS.
  • To determine the prevalence and potential triggers of these symptoms in the CRPS population.

Main Methods:

  • A cohort of 74 patients with CRPS underwent comprehensive cardiac evaluations.
  • These evaluations included electrocardiogram, echocardiography, Holter monitoring, and head-up tilt table testing (HUTT).

Main Results:

  • 10% of CRPS patients could not complete HUTT due to pain; 37.9% reported presyncope/syncope symptoms prior to HUTT.
  • 42.4% of CRPS patients exhibited a positive HUTT, indicating autonomic dysregulation.
  • Lower limb involvement in CRPS correlated with a higher incidence of vasovagal syncope or orthostasis on HUTT (67% vs 33%).

Conclusions:

  • Syncope is a prevalent issue in CRPS, particularly when lower limbs are affected.
  • Autonomic dysregulation in the lower extremities leads to impaired vasoconstriction and venous pooling, predisposing to syncope.
  • Increased physician awareness is crucial for improved recognition and management of presyncope and syncope in CRPS patients.