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[Effect of weight reduction programme on C-peptide concentration and lipid profile in obese children aged 4 to 10

Joanna Gajewska1, Witold Klemarczyk, Jadwiga Ambroszkiewicz

  • 1Zakład Badań Przesiewowych, Instytut Matki i Dziecka w Warszawie. biochem.imid@imid.med.pl

Medycyna Wieku Rozwojowego
|April 6, 2011
PubMed

Insights

Weight reduction in obese children improves lipid profiles and C-peptide levels, aiding metabolic syndrome prevention. This lifestyle intervention is crucial for prepubertal children with abnormal lipid profiles.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Metabolic Disorders

Background:

  • Childhood obesity is linked to metabolic syndrome and cardiovascular risk factors.
  • Limited research exists on weight reduction's impact on atherogenic risk in prepubertal children.

Purpose of the Study:

  • To evaluate C-peptide concentration and lipid profiles in obese prepubertal children.
  • To assess changes before and after a weight reduction therapy program.

Main Methods:

  • A 3-month lifestyle intervention (diet, physical activity, behavior therapy) was applied to 52 obese children (aged 4-10).
  • Anthropometric, C-peptide, and lipid profile parameters were measured pre- and post-intervention.
  • A reference group of 30 healthy children was included for comparison.

Main Results:

  • Obese children who lost weight (Group A) showed significant decreases in triglycerides and C-peptide levels.
  • No significant biochemical changes were observed in obese children without weight loss (Group B).
  • Group B exhibited a slight increase in total and LDL-cholesterol.

Conclusions:

  • Weight reduction programs are essential for prepubertal obese children to prevent metabolic syndrome.
  • The study supports the benefits of weight reduction programs when accepted by children and families.
  • C-peptide may serve as a useful marker for monitoring therapy effectiveness in managing childhood obesity.
Abstract

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