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Updated: Jun 3, 2026
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Published on: March 13, 2026
The effect of both a thoracic trauma and a soft-tissue trauma on fracture healing in a rat model
Lutz Claes1, Anita Ignatius, Raimund Lechner
1Institute of Orthopaedic Research and Biomechanics, Center for Musculoskeletal Research, University of Ulm, Ulm, Germany. lutz.claes@uni-ulm.de
Background And Purpose:
There is some clinical evidence that fracture healing is impaired in multiply injured patients. Nothing is known, however, about the effects of various types of injuries and their contribution to a possible disturbance of the fracture-healing process. We investigated the effect of a thoracic trauma and an additional soft-tissue trauma on fracture healing in a rat tibia model.
Methods:
3 groups of rats were operated: group A with a simple fracture of the tibia and fibula, group B with a fracture and an additional thoracic trauma, and group C with a fracture, thoracic trauma, and an additional soft-tissue trauma. The fracture and the soft-tissue injury were produced by a special guillotine-like device and the thoracic trauma by a blast wave generator. After one day, the serum level of IL-6 was quantified, and at the end of the study (28 days) the mechanical properties and the callus volume of the healed tibia were determined.
Results:
Increasing the severity of the injury caused IL-6 levels to more than double 1 day after injury. It halved the load to failure in mechanical tests and led to reduced callus volume after 28 days of healing.
Interpretation:
Fracture healing is impaired when additional thoracic trauma and soft tissue trauma occurs.
