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Updated: Jun 3, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Antiviral activity of methylelaiophylin, an alpha-glucosidase inhibitor
Doseung Lee1, Jin-Kyu Woo, Donghern Kim
1Faculty of Biotechnology, College of Applied Life Science, Jeju National University, Jeju, Korea.
Abstract:
Methylelaiophylin isolated from Streptomyces melanosporofaciens was selected as an alpha-glucosidase inhibitor with an IC50 value of 10 micrometer. It showed mixedtype inhibition of alpha-glucosidase with a Ki value of 5.94 micrometer. In addition, methylelaiophylin inhibited the intracellular trafficking of hemagglutinin-neuramidase (HN), a glycoprotein of Newcastle disease virus (NDV), in baby hamster kidney (BHK) cells. Methylelaiophylin inhibited the cell surface expression of NDV-HN glycoprotein without significantly affecting HN glycoprotein synthesis in NDV-infected BHK cells.
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