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Related Concept Videos

Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
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Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...

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Deciphering the Molecular Mechanism and Function of Pore-Forming Toxins Using Leishmania major
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A comparative protein function analysis databaseof different Leishmania strains.

Manas Ranjan Dikhit1, Yangya Prasad Nathasharma, Lelin Patel

  • 1BioMedical Informatics Division, Rajendra Memorial Research Institute of Medical Sciences (RMRIMS), Agam kuan, Patna-800007, India.

Bioinformation
|April 6, 2011
PubMed
Summary

A new database provides essential protein functional family and template information for Leishmania species. This resource aids researchers in drug development and protein structure modeling.

Keywords:
CPLComputational proteomics of LeishmaniaLeishmaniadatabasefunctional familyprotein function

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Area of Science:

  • Proteomics and Bioinformatics
  • Drug Discovery
  • Molecular Biology

Background:

  • Understanding protein functional families and template information is crucial for novel drug development.
  • Existing databases for Leishmania strains often lack comprehensive template information and functional family annotations.
  • Protein identification and analysis software are vital for refining protein databases.

Purpose of the Study:

  • To develop a unique, web-based database providing functional family and template information for proteins across different Leishmania species.
  • To facilitate protein tertiary structure modeling based on available template information.
  • To establish relationships between template information and protein functional families identified by SVMProt.

Main Methods:

  • Development of a web-based database by Rajendra Memorial Research Institute of Medical Sciences (RMRIMS).
  • Integration of functional family and template information for proteins from four Leishmania species (L. donovani, L. infantum, L. major, L. braziliensis).
  • Utilization of SVMProt for assigning protein functional families based on template data.

Main Results:

  • The database offers comprehensive descriptions of important proteins in key Leishmania species.
  • It includes a specific characterization table detailing species and functional family information.
  • A significant relationship between template information and assigned protein functional families is facilitated.

Conclusions:

  • The developed database serves as a valuable resource for scientists engaged in proteomics research.
  • It enhances the understanding of Leishmania proteins, supporting drug development initiatives.
  • The database is freely accessible, promoting wider scientific collaboration and research.