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Updated: Jun 3, 2026

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
Published on: February 12, 2022
Update on treatment advances in combined-modality therapy for anal and rectal carcinomas
Jeffrey Meyer1, Glen Balch, Christopher Willett
1Department of Radiation Oncology, UT-Southwestern Medical Center, 5801 Forest Park Road, Dallas, TX 75390-9183, USA. Jeffrey.Meyer@UTSouthwestern.edu
Abstract:
Concurrent radiation therapy and chemotherapy is the primary treatment for patients with squamous cell tumors of the anal canal, and is also employed in the neoadjuvant setting for patients with stage II and III adenocarcinoma of the rectum. There is constant clinical study involving modifications of chemoradiotherapy regimens in an effort to maximize tumor responses while reducing normal tissue toxicity. This review will discuss established regimens as well as newer and novel treatment approaches to treatment of anal and rectal cancer.
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