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Updated: Jun 3, 2026

Methods for Detecting Cough and Airway Inflammation in Mice
Published on: August 2, 2024
GERD-related cough: pathophysiology and diagnostic approach
Jaclyn A Smith1, Rayid Abdulqawi, Lesley A Houghton
1Respiratory Research Group, University of Manchester, ERC Building, Second Floor, Wythenshawe Hospital, Manchester M23 9LT, UK. jacky.smith@manchester.ac.uk
Gastroesophageal reflux may cause chronic cough, but standard acid suppression therapy is often ineffective. This review examines reflux-induced cough, its triggers, and potential mechanisms like laryngopharyngeal reflux and microaspiration.
Area of Science:
- Gastroenterology and Pulmonology
- Investigative Medicine
Background:
- Chronic cough significantly impacts quality of life.
- Gastroesophageal reflux is a leading cause of chronic cough, alongside cough variant asthma and nasal disease.
- Current acid suppression therapies are frequently ineffective for reflux-induced cough.
Purpose of the Study:
- To investigate the causal link between reflux and chronic cough.
- To identify circumstances favoring reflux-induced cough.
- To explore potential mechanisms connecting reflux and cough, including laryngopharyngeal reflux, microaspiration, and neuronal cross-organ sensitization.
Main Methods:
- Literature review focusing on the relationship between gastroesophageal reflux and chronic cough.
- Analysis of proposed pathophysiological mechanisms.
- Evaluation of diagnostic strategies for reflux-induced cough.
Main Results:
- Reflux can indeed precipitate chronic cough through various mechanisms.
- Laryngopharyngeal reflux, microaspiration, and neuronal sensitization are key pathways.
- Diagnostic approaches require careful consideration beyond standard reflux testing.
Conclusions:
- Reflux is a significant contributor to chronic cough, necessitating a deeper understanding of its mechanisms.
- Effective management may require targeted therapies addressing specific reflux-related pathways.
- Further research into diagnostic and therapeutic strategies is warranted.
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