Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Equilibrium and Balance01:15

Equilibrium and Balance

The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
The Vestibular System01:29

The Vestibular System

The vestibular system is a set of inner ear structures that provide a sense of balance and spatial orientation. This system is comprised of structures within the labyrinth of the inner ear, including the cochlea and two otolith organs—the utricle and saccule. The labyrinth also contains three semicircular canals—superior, posterior, and horizontal—that are oriented on different planes.
Anatomy of the Ear01:16

Anatomy of the Ear

Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

E-Cadherin Is an Accurate Target for Fluorescence-Guided Imaging of Lymph Nodes.

Current issues in molecular biology·2026
Same author

GJB2-Related Hearing Loss: Genotype-Phenotype Correlations, Natural History, and Emerging Therapeutic Strategies.

International journal of molecular sciences·2026
Same author

Dementia Care Research and Psychosocial Factors.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same journal

How does Léri-Weill Dyschondrosteosis Affect Adults' Health-Related Quality of Life? - A Norwegian Cross-Sectional Study Exploring the Physical and Mental Burden.

American journal of medical genetics. Part A·2026
Same journal

Re-Identification of the Panamanian Guna/Kuna/Cuna OCA2 Founder Association Through Two American-Born Siblings.

American journal of medical genetics. Part A·2026
Same journal

Biallelic Variant in HAPLN1 is Associated With Skeletal Dysplasia With or Without Congenital Heart Disease.

American journal of medical genetics. Part A·2026
Same journal

MYH11-Related Hereditary Type 2 Visceral Myopathy in a Large Kindred: Diagnostic Odyssey With Milder Clinical Manifestations.

American journal of medical genetics. Part A·2026
Same journal

Positron Emission Tomography (PET) in Phenylketonuria: A Systematic Review of Brain Metabolism Beyond Phenylalanine.

American journal of medical genetics. Part A·2026
Same journal

Re: "Clinical Insights From a Case of Sifrim-Hitz-Weiss Syndrome With a CHD4 Variant: Expanding the Phenotypic Spectrum and Its Response to Growth Hormone Therapy".

American journal of medical genetics. Part A·2026
See all related articles

Related Experiment Video

Updated: Jun 3, 2026

Three Dimensional Vestibular Ocular Reflex Testing Using a Six Degrees of Freedom Motion Platform
10:12

Three Dimensional Vestibular Ocular Reflex Testing Using a Six Degrees of Freedom Motion Platform

Published on: May 23, 2013

Vestibular dysfunction in DFNB1 deafness.

Kelley M Dodson1, Susan H Blanton, Katherine O Welch

  • 1Department of Otolaryngology, Virginia Commonwealth University, Richmond, USA. kdodson@mcvh-vcu.edu

American Journal of Medical Genetics. Part A
|April 6, 2011
PubMed
Summary
This summary is machine-generated.

Vestibular dysfunction, including vertigo, is a common but often overlooked symptom in individuals with DFNB1 deafness caused by GJB2 and GJB6 mutations. This condition significantly impacts daily life for many affected patients.

Related Experiment Videos

Last Updated: Jun 3, 2026

Three Dimensional Vestibular Ocular Reflex Testing Using a Six Degrees of Freedom Motion Platform
10:12

Three Dimensional Vestibular Ocular Reflex Testing Using a Six Degrees of Freedom Motion Platform

Published on: May 23, 2013

Area of Science:

  • Genetics
  • Otolaryngology
  • Neurology

Background:

  • Mutations in GJB2 and GJB6 (connexin-26 and 30) at the DFNB1 locus are the primary genetic cause of autosomal recessive, nonsyndromic deafness.
  • Despite widespread expression of connexins in the vestibular system, vestibular dysfunction is not widely recognized as a common feature of DFNB1 deafness.

Purpose of the Study:

  • To investigate the prevalence of vestibular dysfunction in patients with DFNB1 deafness.
  • To compare vestibular dysfunction rates between DFNB1 deafness cases and controls with other forms of deafness.

Main Methods:

  • A survey was developed to assess vestibular dysfunction symptoms, medical, and family history.
  • The survey was distributed to individuals with DFNB1 deafness (Cases) and deaf individuals without DFNB1 mutations (Controls).
  • Data from 235 Cases and 121 Controls were analyzed.

Main Results:

  • Vestibular dysfunction was reported by 54% of DFNB1 deafness Cases, significantly higher than in Controls (P < 0.03).
  • Vertigo interfered with daily activities for 48% of Cases, with 63% requiring rest to alleviate symptoms.
  • Truncating mutations and a family history of dizziness were associated with increased vertigo incidence.

Conclusions:

  • Vestibular dysfunction is a more frequent clinical feature of DFNB1 deafness than previously understood.
  • The findings highlight the need to consider vestibular assessment in patients diagnosed with DFNB1-related hearing loss.
  • Vestibular dysfunction associated with DFNB1 deafness significantly impacts patients' quality of life.