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Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents

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Nutritional phases in Prader-Willi syndrome.

Jennifer L Miller¹, Christy H Lynn, Danielle C Driscoll

¹Department of Pediatrics, College of Medicine, University of Florida, Gainesville, 32610-0296, USA.

American Journal of Medical Genetics. Part A

|April 6, 2011

Summary

Prader-Willi syndrome (PWS) nutritional phases are more complex than previously thought, with seven distinct stages identified. Understanding these phases is key to developing targeted therapies and managing obesity in PWS patients.

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Area of Science:

Genetics and Metabolic Disorders
Neurobehavioral Syndromes
Pediatric Endocrinology

Background:

Prader-Willi syndrome (PWS) is traditionally characterized by two distinct nutritional stages: infantile feeding difficulties and later hyperphagia leading to obesity.
Previous models oversimplified the complex feeding behaviors and metabolic changes observed throughout an individual's life with PWS.

Purpose of the Study:

To longitudinally characterize the growth, metabolic, and laboratory changes associated with the various nutritional phases in a large cohort of individuals with PWS.
To refine the understanding of PWS nutritional progression beyond the classical two-stage model.

Main Methods:

Longitudinal follow-up of feeding behaviors in individuals with PWS.
Analysis of growth, metabolic parameters, and laboratory data across identified nutritional phases.
Cohort study involving a large number of PWS subjects.

Main Results:

Identification of seven distinct nutritional phases in PWS, including a prenatal phase (Phase 0) and five main phases with sub-phases (Phase 1a, 1b, 2a, 2b, 3, 4).
Detailed description of the characteristics, age of onset, and progression through each phase, from in utero growth restriction to potential resolution of hyperphagia.
Demonstration of a more gradual and complex nutritional trajectory than previously recognized.

Conclusions:

The nutritional progression in PWS is significantly more intricate than the traditional two-stage model suggests.
Recognizing these seven phases provides a foundation for investigating the pathophysiology of each stage and developing targeted therapies.
Informing parents about these phases can aid in managing and potentially preventing early-onset obesity in children with PWS.