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Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
Published on: April 25, 2014
Drug resistance patterns in pulmonary tuberculosis
Haji Khan Khoharo1, Imran Ali Shaikh
1Department of Medicine, Muhammad Medical College Hospital, Mirpurkhas.
JPMA. the Journal of the Pakistan Medical Association
|April 7, 2011
Summary
High rates of drug-resistant tuberculosis (DR-TB) were found, particularly multidrug-resistant tuberculosis (MDR-TB), in category II patients. Primary MDR-TB also appeared in category I patients, indicating community spread.
Area of Science:
- Microbiology
- Infectious Diseases
- Public Health
Background:
- Tuberculosis (TB) remains a significant global health challenge, with drug resistance complicating treatment outcomes.
- Understanding resistance patterns in different patient categories is crucial for effective TB control strategies.
Purpose of the Study:
- To investigate the drug resistance patterns of Mycobacterium tuberculosis (MTB) isolates in pulmonary tuberculosis (PTB) patients categorized as I and II.
- To identify the prevalence of drug-resistant TB (DR-TB) and multidrug-resistant TB (MDR-TB) within these patient groups.
Main Methods:
- A cross-sectional study involving 890 PTB patients (November 2008-September 2009).
- Sputum samples were cultured on Lowenstein-Jensen media, and Drug Sensitivity Testing (DST) was performed for Isoniazid, Rifampicin, Ethambutol, Pyrazinamide, and Streptomycin.
- Data from 285 culture-positive cases were analyzed using SPSS, with a p-value <0.05 considered significant.
Main Results:
- Overall, 71.92% of isolates were drug-resistant (p=0.001), with MDR-TB detected in 42.10% of cases.
- Higher rates of MDR-TB were observed in category II patients (57.50%) compared to category I patients (5.88%) (p=0.0001).
- Individual drug resistance rates were highest for Isoniazid (51.22%) and Rifampicin (15.4%).
Conclusions:
- Drug-resistant and multidrug-resistant tuberculosis are prevalent, predominantly in category II patients.
- The presence of primary MDR-TB in category I patients suggests community-level dissemination of resistant strains.
- These findings highlight the urgent need for enhanced TB surveillance and treatment strategies to combat rising drug resistance.
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