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Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
Published on: June 26, 2018
Current status on natural products with antitumor activity from Brazilian marine sponges
Mario Junior Luiz Conte da Frota1, Renata Biegelmeyer da Silva, Beatriz Mothes
1Centro de Estudos em Estresse Oxidativo (CEEO), ICBS-UFRGS, Porto Alegre, Brazil.
Abstract:
Over the last few years, samples from the marine environment have been screened for a variety of compounds with different biological activities. Among all marine organisms, sponges represent one of the most promising sources of leads in the research of new cancer drugs. However, there are few reports on screening Brazilian marine sponges for biological activities. In the following review, the current status of natural product research relating to Brazilian marine sponges is summarized, particularly for compounds demonstrating potential antitumor activity.
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