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Updated: Jun 3, 2026

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection
Published on: May 7, 2020
[Meningeal irritation]
Rob Dijcks1, Marloes Derks, Maarten Verwijnen
1Maastricht Universitair Medisch Centrum, Skillslab, Maastricht, the Netherlands.
Abstract:
Diagnosing meningitis requires the information from both history-taking and physical examination in its entirety. In adults with a history that makes meningitis a possibility, specific tests used to diagnose meningeal irritation, such as for Kernig or Brudzinski signs or nuchal rigidity, probably do not affect the reliability of the diagnosis. In small children and the elderly, Kernig and Brudzinski signs are also probably of little or no diagnostic value.
Insights
Diagnosing meningitis relies on comprehensive patient history and physical exams. Specific tests for meningeal irritation, like Kernig
Area of Science:
- Neurology
- Infectious Diseases
- Clinical Diagnostics
Context:
- Meningitis diagnosis relies on a combination of patient history and physical examination findings.
- The diagnostic utility of specific physical examination signs for meningeal irritation is under review.
Purpose:
- To evaluate the diagnostic value of specific physical examination maneuvers in suspected meningitis cases.
Summary:
- In adults with suspected meningitis, tests for meningeal irritation (Kernig's sign, Brudzinski's sign, nuchal rigidity) likely do not significantly alter diagnostic reliability.
- These specific signs appear to have minimal to no diagnostic value in diagnosing meningitis in very young children and the elderly.
Impact:
- Findings may refine diagnostic protocols for meningitis, emphasizing clinical history and overall examination over isolated physical signs.
- This could lead to more efficient and potentially more accurate diagnostic pathways, especially in vulnerable populations.
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