Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biomonitoring Equivalents for select neonicotinoids.

Regulatory toxicology and pharmacology : RTP·2026
Same author

Evaluation of the modes of action for key noncancer effects of 1,3-Butadiene: input from an independent expert panel to support derivation of data-derived extrapolation factors.

Critical reviews in toxicology·2026
Same author

Biomonitoring Equivalents for interpreting mandelic and phenylglyoxylic acid in urine resulting from exposures to styrene and ethylbenzene.

Regulatory toxicology and pharmacology : RTP·2026
Same author

PFOS and PFOA exposure induces liver injury and sex-dependent immune effects in C57BL/6 mice.

iScience·2026
Same author

The Creation of a Weight of Evidence Scoring Database for Risk Factors for Adverse Impacts to Birth Outcomes Using Expert Elicitation.

Birth defects research·2026
Same author

Improving the design of epidemiology studies that use biomonitoring for exposure assessment: a SciPinion panel recommendation.

BMC medical research methodology·2026

Related Experiment Video

Updated: Jun 3, 2026

Determination of 45 Pesticides in Avocado Varieties by the QuEChERS Method and Gas Chromatography-Tandem Mass Spectrometry
05:20

Determination of 45 Pesticides in Avocado Varieties by the QuEChERS Method and Gas Chromatography-Tandem Mass Spectrometry

Published on: December 8, 2023

Biomonitoring equivalents for deltamethrin.

Lesa L Aylward1, Kannan Krishnan, Christopher R Kirman

  • 1Summit Toxicology, LLP, Falls Church, VA 22044, USA. laylward@summittoxicology.com

Regulatory Toxicology and Pharmacology : RTP
|April 7, 2011
PubMed
Summary

Biomonitoring Equivalents (BEs) were established for deltamethrin, a pyrethroid insecticide, using plasma and urine biomarkers. These BEs provide screening criteria for assessing human exposure levels in biomonitoring studies.

More Related Videos

Analysis of Organochlorine Pesticides in a Soil Sample by a Modified QuEChERS Approach Using Ammonium Formate
04:17

Analysis of Organochlorine Pesticides in a Soil Sample by a Modified QuEChERS Approach Using Ammonium Formate

Published on: January 20, 2023

Topical Application Bioassay to Quantify Insecticide Toxicity for Mosquitoes and Fruit Flies
09:37

Topical Application Bioassay to Quantify Insecticide Toxicity for Mosquitoes and Fruit Flies

Published on: January 19, 2022

Related Experiment Videos

Last Updated: Jun 3, 2026

Determination of 45 Pesticides in Avocado Varieties by the QuEChERS Method and Gas Chromatography-Tandem Mass Spectrometry
05:20

Determination of 45 Pesticides in Avocado Varieties by the QuEChERS Method and Gas Chromatography-Tandem Mass Spectrometry

Published on: December 8, 2023

Analysis of Organochlorine Pesticides in a Soil Sample by a Modified QuEChERS Approach Using Ammonium Formate
04:17

Analysis of Organochlorine Pesticides in a Soil Sample by a Modified QuEChERS Approach Using Ammonium Formate

Published on: January 20, 2023

Topical Application Bioassay to Quantify Insecticide Toxicity for Mosquitoes and Fruit Flies
09:37

Topical Application Bioassay to Quantify Insecticide Toxicity for Mosquitoes and Fruit Flies

Published on: January 19, 2022

Area of Science:

  • Environmental Health
  • Toxicology
  • Biomonitoring

Background:

  • Biomonitoring provides integrated exposure assessment via multiple routes.
  • Quantitative screening criteria are needed to interpret biomonitoring data in risk assessments.

Purpose of the Study:

  • Derive Biomonitoring Equivalents (BEs) for the synthetic pyrethroid deltamethrin.
  • Establish screening criteria for deltamethrin exposure using plasma and urinary biomarkers.

Main Methods:

  • BEs were derived for deltamethrin in plasma and its metabolite DBCA in urine.
  • Extrapolation from rat studies and human pharmacokinetic data were used.
  • BEs were linked to established risk assessment guidance values (RfDs, ADIs).

Main Results:

  • BE values for deltamethrin in plasma: 20 μg/L (adults) and 2 μg/L (children) based on USEPA RfD.
  • BE values for DBCA in urine: 50 μg/L (adults) and 7 μg/L (children) based on RfDs.
  • Urinary BE for DBCA: 60 μg/L based on European ADI.

Conclusions:

  • Derived BE values serve as crucial screening tools for deltamethrin biomonitoring data.
  • These values facilitate the interpretation of exposure in the context of established health-based guidance values.
  • The study provides a framework for assessing human exposure to deltamethrin.